Source: “Little Orange Lamp” official WeChat public account (ivdnet)
Original Title: The World's Innovative Commercial Digital Isothermal Amplification System, ISO Digital, Makes Its Debut in Shanghai
March 7, 2024, Shanghai, China - Turtle Technology officially launched the ISO Digital digital isothermal amplification system in Shanghai, marking a new era in the commercialization of digital isothermal amplification technologies such as digital LAMP.
While isothermal amplification technologies including LAMP, RPA, ERA have long been of interest and have found relatively widespread applications in areas such as clinical fast testing, their inability to provide precise quantification has limited their broader use. In addition to precise quantification, digital isothermal amplification offers the following advantages compared to conventional isothermal amplification and PCR technologies:
Inspired by digital PCR technology, achieving precise quantification in isothermal amplification has become a focal point of research and development in both academic and industrial circles. However, as of now, there has yet to be a digital isothermal amplification system that has truly achieved commercialization. The ISO Digital system introduced by Turtle Technology is poised to become the world's innovative digital isothermal amplification system capable of large-scale commercialization.
The primary challenge of digital isothermal amplification technology lies in the high viscosity of the amplification reagents, making it difficult to form uniform and stable droplets. Additionally, isothermal amplification reactions can be rapidly initiated at room temperature, necessitating strict control over the time from reagent mixing to droplet generation for each sample.
Turtle Technology's ISO Digital platform addresses these challenges perfectly. The platform adopts an innovative solidified-oil-water partitioning technology with extremely high droplet stability, segregating the reagents into over 20,000 microchambers on the chips. Through a fully automated First in, First out (FIFO) multi-sample control scheme, the platform ensures strict consistency in the time from reagent mixing to droplet generation for each sample. The ISO Digital platform is not only compatible with mainstream digital LAMP, digital ERA, and digital RPA functions but also features digital PCR functionality. It is expected to be a groundbreaking advancement in the development of life sciences and precision medicine, providing researchers and clinical practitioners with more advanced and efficient technological tools.
(The news is reposted from the official WeChat public account of "Little Orange Lamp" Web. For reposting, please contact the source.)
About Turtle Technology
Turtle Technology is committed to leading the life sciences and molecular diagnostics into the digital era. Having been approved as the National Demonstration Center for Genetic Testing Technology and obtaining the first Digital PCR Metrological Evaluation Certificate, we have introduced a variety of digital PCR systems. This marks a comprehensive technological innovation across the entire industrial chain, including genetic testing instruments, chip consumables, Ultra-Multiplex technology, and ultra-high specificity polymerase.
